International Journal of Medical Laboratory Research (IJMLR)

KIDNEY FUNCTIONS IN WISTER RATS TREATED WTH ARTESUNATE AND AMODIAQUINE

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Adeyomoye O.I, Adeleye A.S.

 

ABSTRACT: Malaria is a mosquito bone disease caused by plasmodium parasite. Several drugs have been developed and used in treatment of this disease but, many of these medications results in adverse side effects. This study evaluates the effects of artesunate and amodiaquine (antimalaria agents) in renal functions of wister rats. Fifteen wister rats were divided into 3groups (n=5). Group 1 served as normal control, groups 2 and 3 were treated with 8mg/kg artesunate and 30mg/kg amodiaquine respectively for 5 days after which blood samples were collected and centrifuged to obtain serum. Blood urea nitrogen (BUN) and Creatinine (CRT) levels were determined using randox kits. Kidney histology was done using haematoxylin-eosin stain. Results were analyzed using one way ANOVA with statistical significance taken at p<0.05. BUN increased significantly in 30mg/kg amodiaquine treated rats when compared with normal control and 8mg/kg artesunate treated rats. There was also significant increase in creatinine level in 30mg/kg amodiaquine treated rats when compared with normal control and 8mg/kg artesunate treated rats. Histological sections shows glomeruli distortions in both artesunate and amodiaquine treated rats. Artesunate increased BUN while amodiaquine increased both BUN and CRT which are potentially toxic at high concentrations. Artesunate may therefore be a preferred medication over amodiaquine in malaria treatment because of its reduced side effects on kidney functions.

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KEY WORDS: Malaria, artesunate, amodiaquine, medication, renal function

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