Letter to Editor

      Abstract    

        

COVID-19 AND BLOOD BANK: ROLE OF PATHOGEN INACTIVATION

N Bansal, Y Bansal

 

ABSTRACT: In December 2019, a new coronavirus named severe acute respiratory syndrome virus (SARS-CoV-2) causing pneumonia was detected in Wuhan, China. The recognition of newly described infectious agents poses a threat to blood safety. In a study on COVID-19 patients, RNAaemia (presence of 2019-nCoV RNA in plasma of the patient) has been seen in 15% (6/41) of the cases. Therefore, because of a long asymptomatic but viremic phase there is a theoretical risk of transmission of COVID-19 through blood transfusion and careful surveillance is required with regards to blood safety. We highlight the role of incorporation of pathogen inactivation techniques in blood components to prevent transfusion transmission of newer emerging pathogens.

 

KEY WORDS: Coronavirus; Pathogen Inactivation; Newer emerging pathogens

REFERENCES:

  1. Stramer SL, Hollinger FB, Katz LM, et al. Emerging infectious disease agents and their potential threat to transfusion safety. Transfusion  2009; 49:1S­-29S

  2. Chan JFW, Yuan S, Kok KH, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020.

  3. Lai CC, Liu YH, Wang CY. Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome corona virus 2 (SARS-CoV-2): Facts and myths. J Microbiol Immunol Infect 2020; 53,3:404-412.

  4. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020.

  5. Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. .Int J Antimicrob Agents. 2020; 55,3:105924.

  6. Ministry of Health and Family Welfare. Advisory for Voluntary Blood Donation during COVID-19 scenario https://www.mohfw.gov.in/pdf/NBTCGUIDANCEFORCOVID19.pdf; 2020 [assessed 2020-4-20]

  7. Hashem AM, Hassan AM, Tolah AM, et al. Amotosalen and ultraviolet A light efficiently inactivate MERS-coronavirus in human platelet concentrates. Transfus Med 2019; 29:434-­41.

 To cite this article:

Bansal N, Bansal Y. Covid-19 and blood bank: role of pathogen inactivation. Int. J. Med. Lab. Res. 2020; 5,2:77-79. http://doi.org/10.35503/IJMLR.2020.5210

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