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Research Article





Jari Intra, Claudia Siracusa, Maria Roberta Sala, Valerio Leoni, Paolo Brambilla, Davide Carcione


ABSTRACT: We retrospectively analyzed the antimicrobial data of P. aeruginosa strains isolated from hospitalized subjects and outpatients over a 20-year period (2000-2019). A total of 2,588 unique P. aeruginosa strains, 588 from outpatients (23 %) and 2,000 from hospitalized subjects (77 %), were retrieved. Except gentamicin and ciprofloxacin, which showed significant antibiotic decreasing trends, all the antimicrobial agents tested did not show significantly changes in both groups (p < 0.01). There were significant increasing resistance trends for all antibiotics, except gentamicin and ciprofloxacin in P. aeruginosa strains isolated from respiratory tract samples (p < 0.05), and for meropenem and piperacillin-tazobactam in urine samples from subjects with and without urinary catheter (p < 0.05). Moreover, there was a significant increase in multidrug resistant isolates (p < 0.05). Monitoring antibiotic resistances at local and regional levels are required in order to reduce inappropriate antimicrobial consumption, to increase the focus on antimicrobial stewardship.


KEY WORDS: Antibiotic resistance, Pseudomonas aeruginosa, Epidemiology, Carbapenem resistance, Surveillance


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 To cite this article:

Intra J, Siracusa C, Sala MR, Leoni V, Brambilla P, Carcione D. Twenty-year trends in antimicrobial resistances among pseudomonas aeruginosa clinical isolates. Int. J. Med. Lab. Res. 2021; 6,3:27-34.

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