Research Articles






Shabeer S Iqbal , Lapin. A , Anju P , Deeshma P , Athulya K 


ABSTRACT: Back ground: No single laboratory test is sufficient to have adequate specificity to find out the exact reason behind the neonatal jaundice and therefore the laboratory evidence must be used in coordination with risk factors, medical signs & symptoms. Hence, we have decided to evaluate the relevance of liver function tests in pre-term and full-term babies with neonatal jaundice. Study design: The present study was conducted to assess the significance of Liver function test (LFT) parameters in full-term and pre-term babies with neonatal jaundice.  Materials & methods: The study was carried out at Kannur medical college, Anjarakandy during the year of 2017. A total of 50 newborn babies with neonatal jaundice (25 full term and 25 pre-term) were chosen for this study. Serum samples were collected and Liver Function tests (LFT) such as serum bilirubin, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Total protein (TP) and albumin were estimated. Results: The result showed that the serum level of total bilirubin (TB), indirect bilirubin (IDB), AST, ALT and ALP were significantly increased in pre-term than in the case of full-term neonates. There was no significant variation in bilirubin, albumin & TP level.  Conclusion: Outcome of this study suggests that there is an observable significant variation in Liver function tests parameters in pre-term and full-term babies. The results, also indicate that preterm babies will be more prone to severe neonatal jaundice when compared to full term babies.


KEY WORDS: LFT, neonates, term pregnancy, ALT, AST, bilirubin


  1. American Academy of Pediatrics. Practice Parameter: management of hyperbilirubinemia in the healthy term newborn. Pediatrics; 1994; 94:558–62

  2. Clarke LC, Beck E. Plasma alkaline phosphatase activity, Normative data for growing children”. J Pediatr; 1950; 36:335–41.

  3. David BS, Martin H, Ashoka DC. Understanding neonatal jaundice: UK practice and international profile  Perspective in Public Health; 2008; 128(4): 202-206

  4. Dennery PA, Seidman DS, Stevenson DK. Neonatal hyperbilirubinemia. N Engl J Med 2001; 344:581-90.

  5. Masayuki O, Yuki M, Hirosuke I, Takeshi K, Dongchon K, Kiyoshi I, et al,. Blood Reference Intervals for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan. PLoS One. 2016; 11(8).

  6. Gartner LM, Herschel M. Jaundice and breast feeding. Pediatr Clin North Am 2001;48:389-

  7. Meites S. Pediatric clinical chemistry reference (normal) values. 3rd ed. Washington, DC: AACC Press, 1989:37–43.

  8. Melton K, Akinbi HT. Neonatal jaundice. Strategies to reduce bilirubin-induced complications. Post- grad Med 1999; 106:167-8,171-4,177-8.

  9. Meredith LP and Beth LD. Hyperbilirubinemia in the Term Newborn. Am Fam Physician 2002;65:599-606,613-4

  10. Morse RP, Rosman NP. Diagnosis of occult muscular dystrophy: importance of the “chance” finding of elevated serum aminotransferase activities”. J Pediatr; 1993; 122:254–6.

  11. Rachel C, Julie D, Lindsay F, Jacqueline D, Margi D, Jennifer H. An osteopathic approach to reduction of readmissions for neonatal jaundice". Osteopathic Family Physician. Journal of Biosciences and Medicines; 2013; 3 (2):201-212.

  12. Soldin SJ, Hicks JM. Alkaline phosphatase (ALP). In: Pediatric reference ranges. Washington, DC: AACC Press, 1995:5.

  13. Treem WR. Persistent elevation of transaminases as the presenting finding in an adolescent with an unsuspected muscle glycogenosis”. Clin Pediatr; 1987; 26:605–7.

  14. Vasudevan DM, Sreekumari S and Kannan V. Text book of biochemistry for medical students. 7th edi. New Delhi: JAYPEE Brothers publication;2013.p. 346.

  15. Walters EG, Murphy JF, Henry P, Gray OP, Elder GH. Plasma alkaline phosphatase activity and its relation to rickets in pre-term infants.Ann Clin Biochem 1986; 23:652-6.

  16. Watchko JF, Maisels MJ. Jaundice in low birth weight infants: pathobiology and outcome. Arch Dis Child Fetal Neonatal Ed. 2003; 88(6): 455–F458

  17. Wintrobe MM, Lee GR. Wintrobe’s Clinical hematology. 10th ed. Baltimore: Williams & Wilkins, 1999:267-89..

  18. Zanardo V, Perini G. Aspartate aminotransferase and alanine aminotransferase serum activities in small-for-date newborns. Padiatr Padol. 1987; 22(4):325-30.