Research Article

      Abstract    

        

THE VALUE OF NEUTROPHIL TO LYMPHOCYTE RATIO, PLATELET COUNT AND RED CELL DISTRIBUTION WIDTH TO PLATELET RATIO AS PROGNOSTIC MARKERS IN BURN PATIENTS

Geet Bhuyan, Chintamani Pathak , Sunil Ranga 

 

ABSTRACT: Background: The aim of the study was to find a relationship between neutrophil to lymphocyte ratio (NLR), platelet count and red cell distribution width to platelet ratio (RPR) and mortality in burn patients and whether these parameters can be used to predict the outcome in these patients. Material and methods: The retrospective study was performed on 242 patients admitted in the department of burns and plastics between February 2019 and December 2019. The study population was further divided into two groups i.e the discharge group (group 1) and the mortality group (group2).  Demographic information in both groups such as age, gender, burn scores, neutrophil counts, lymphocyte counts, platelet counts and RDW during admission to the hospital was recorded. NLR and RPR were calculated using the patient’s complete blood count (CBC). Results: NLR was higher in the mortality group (14.44±6.95) in comparison to the discharge group (7.23±3.25). RPR values were also noticeably higher in the mortality group (0.312±0.124) when compared to the discharge group (0.067±0.029). Whereas platelet count was seen to be lower in the mortality group (92.24±74.01) as compared to the discharge group (162.84±82.52). Each of the above results were statistically significant (p=0.00). These results correlated with a higher R-BAUX score that was seen in the mortality group. Conclusion: NLR, RPR and platelet count can be effectively used as prognostic markers to monitor the progression in burn patients.

 

KEY WORDS: Neutrophil to lymphocyte ratio, platelet count, red cell distribution width to platelet ratio, burn, complete blood count.

REFERENCES:

  1. Kaddoura I, Abu-Sittah G, Ibrahim A, Karamanoukian R, Papazian N. Burn injury: review of pathophysiology and therapeutic modalities in major burns. Ann Burns Fire Disasters. 2017;30,2:95‐102.

  2. Burns [Internet]. Who.int. 2020 [cited 17 April 2020]. Available from: https://www.who.int/news-room/fact-sheets/detail/burns

  3. Burns | National Health Portal Of India [Internet]. Nhp.gov.in. 2020 [cited 17 May 2020]. Available from: https://www.nhp.gov.in/disease/skin/burns

  4. Halgas B, Bay C, Foster K. A comparison of injury scoring systems in predicting burn mortality. Ann Burns Fire Disasters. 2018;31,2:89‐93.

  5. Egea-Guerrero JJ, Martínez-Fernández C, Rodríguez-Rodríguez A, Bohórquez-López A, Vilches-Arenas A, Pacheco-Sánchez M et al. The utility of C-reactive protein and procalcitonin for sepsis diagnosis in critically burned patients: A preliminary study. Plast Surg (Oakv). 2015;23,4:239-43.

  6. Mokline A, Garsallah L, Rahmani I, et al. Procalcitonin: a diagnostic and prognostic biomarker of sepsis in burned patients. Ann Burns Fire Disasters. 2015;28,2:116‐120.

  7. Meijs J, Dokter J, Van Baar M, Oen I, Van der Vlies C. O23.4 External validation of the Revised Baux Score for prediction of mortality in patients with acute burn injury. Burns. 2011;37:S15.

  8. Tan YG, Eu EWC, Huang HH, Lau WKO. High neutrophil-to-lymphocyte ratio predicts worse overall survival in patients with advanced/metastatic urothelial bladder cancer. Int J Urol. 2018;25,3:232‐238.

  9. Haram A, Boland MR, Kelly ME, Bolger JC, Waldron RM, Kerin MJ. The prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer: A systematic review. J Surg Oncol. 2017;115,4:470‐479.

  10. Zhang B, Du W, Gan K, Fang Q, Zhang X. Significance of the neutrophil-to-lymphocyte ratio in young patients with oral squamous cell carcinoma. Cancer Manag Res. 2019;11:7597‐7603.

  11. Angkananard T, Anothaisintawee T, McEvoy M, Attia J, Thakkinstian A. Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis. Biomed Res Int. 2018;2018:2703518.

  12. Alkan Ozdemir S, Arun Ozer E, Ilhan O, Sutcuoglu S. Can neutrophil to lymphocyte ratio predict late-onset sepsis in preterm infants?. J Clin Lab Anal. 2018;32,4 :e22338.

  13. Yuyun D, Zhihua T, Haijun W, Zhaoping L, Xiaoli Z, Wenfang X et al. Predictive value of the red blood cell distribution width-to-platelet ratio for hepatic fibrosis. Scand J Gastroenterol. 2019;54,1:81-86

  14. Cetinkaya E, Senol K, Saylam B, Tez M. Red cell distribution width to platelet ratio: new and promising prognostic marker in acute pancreatitis. World J Gastroenterol. 2014;20,39:14450‐14454.

  15. Pusuroglu H, Cakmak HA, Akgul O, Erturk M, Surgit O, Akkaya E, Bulut U, Yildirim A. The prognostic value of admission red cell distribution width-to-platelet ratio in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Rev Port Cardiol. 2015;34,10:597-606.

  16. Nielson CB, Duethman NC, Howard JM, Moncure M, Wood JG. Burns: Pathophysiology of Systemic Complications and Current Management. J Burn Care Res. 2017;38,1:e469-e481.

  17. Gajbhiye AS, Meshram MM, Kathod AP. Platelet count as a prognostic indicator in burn septicemia. Indian J Surg. 2013 Dec;75,6:444-8.

  18. Rohl J, Zaharia A, Rudolph M, Murray RZ. The role of inflammation in cutaneous repair. Wound Practice & Research: Journal of the Australian Wound Management Association. 2015;23,1:8-12.

  19. Strudwick X, Cowin A. The Role of the Inflammatory Response in Burn Injury. Rijeka: IntechOpen [Internet]. 2018 [cited 14 June 2020];. Available from: https://www.intechopen.com/books/hot-topics-in-burn-injuries/the-role-of-the-inflammatory-response-in-burn-injury

  20. Jacob S, Herndon DN, Hawkins HK, Enkhbaatar P, Cox RA. Xanthine oxidase contributes to sustained airway epithelial oxidative stress after scald burn. Int J Burns Trauma. 2017;7,6:98-106.

  21. Keskin H, Kaya Y, Cadirci K, Kucur C, Ziypak E, Simsek E et al. Elevated neutrophil-lymphocyte ratio in patients with euthyroid chronic autoimmune thyreotidis. Endocr Regul. 2016;50,3:148-53.

  22. Ali C. Could neutrophil-to-lymphocyte ratio be a new mortality predictor value in severe burns?. Journal of Surgery and Surgical Research. 2019:026-028.

  23. Fuss J, Voloboyeva A, Poliovyj V. Prognostic value of using neutrophil-lymphocyte ratio in patients with burn injury for the diagnosis of sepsis and bacteraemia. Pol Przegl Chir. 2018;90,5:13-16.

  24. Qiu L, Chen C, Li SJ, Wang C, Guo F, Peszel A, Liu S, Wang F, Sun YX, Wang YJ, Chen XL. Prognostic values of red blood cell distribution width, platelet count, and red cell distribution width-to-platelet ratio for severe burn injury. Sci Rep. 2017 Oct 20;7,1:13720.

 To cite this article:

Geet B , Chintamani P , Sunil R .The value of neutrophil to lymphocyte ratio, platelet count and red cell distribution width to platelet ratio as prognostic markers in burn patients. Int. J. Med. Lab. Res. 2020; 5,3:19-23. http://doi.org/10.35503/IJMLR.2020.5303

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