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Review Article





V Rathod, U Kousar, C Leelambika, P Shankar


ABSTRACT: Background and Aim: This article aims to analyze liver enzymes in relation to COVID-19 patients by performing a systematic review of articles which describe the changes in liver enzymes in COVID 19.  Abnormalities of liver enzymes associated with Covid-19 has been well documented by a number of articles since the start of the pandemic and could be used to monitor the disease progression .hence, this review was done to understand better the effect of covid 19 on liver enzymes. Methods: A systematic review to describe existing literature with regard to liver enzyme changes in SARS CoV-2 disease to understand the pattern of variations in  ALT and  AST. Articles for Literature review were accessed from the PubMed and other sources.On the day of admission and during hospitalization, LFT was done in COVID-19 patients. Median age 47 years (Inter Quarantile Range 33-61). The age group and cut off values for LFT is based on the Institutional board of the “National Health Commission of China”. Result: We reviewed original articles from 15 International Journals related to COVID-19 and liver enzymes and found that the liver enzymes (ALT, AST) are significantly elevated in pre-existing and non-pre-existing liver disorder in COVID-19 patients. In the present study we have analysed 2811 patients (which were described in the reviewed original articles) with both pre and non-pre-existing liver injury. Out of 2811 patients the AST was elevated in 471 patients and ALT was elevated in 530 patients.Among them 2,279 patients are with pre-existing liver disease, where AST elevated in 371(25.53%) and ALT was elevated in 401(23.87%) patients. 532 patients are with non-pre-existing liver disease, where AST elevated in 100 (26.6%) and ALT in 129 (21.7%) patients. Conclusion: Liver enzymes are elevated both in the pre-existing and non-existing liver disease in COVID-19 patients. Although  increase in ALT and AST was more noticed in patients with pre-existing liver disease, a significant percentage of  patients without any pre-existing liver abnormalities also showed a  high transaminase value.

KEY WORDS: Alanine transaminase (ALT) Aspartate amino transaminase (AST).


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 To cite this article:

Rathod V, uzma Kousar U, Leelambika C, Shankar P. A systematic review of pandemic covid-19 basesd on liver enzymes. Int. J. Med. Lab. Res. 2020; 5,2:33-39.

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