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Case study





 M Kumari, C Ahluwalia


ABSTRACT: Primary cutaneous lymphomas (PCL) are defined as non-Hodgkin lymphomas presenting in the skin with no evidence of extra-cutaneous disease at the time of diagnosis and at 6-months follow up. Among these primary cutaneous T cell lymphomas are more common than primary cutaneous B cell lymphoma (PCBCL). Primary cutaneous diffuse large B cell lymphoma commonly occurs on the legs (leg type), rarely on other sites of the body. The clinical manifestations are so complex that its diagnosis depends on histopathological and immune-histochemical examinations. We here present a case of 77-years old male who presented with an ulcero-proliferative over left cheek.


KEY WORDS: Primary cutaneous diffuse large B cell lymphoma, cheek, ulcero-proliferative lesion


  1. Puches R, Zenahlik P, Bäck B, Smolle J, Kerl H, Cerroni L.Primary cutaneous lymphomas: Applicability of currentclassification schemes (European Organization for Research and Treatment of Cancer, World Health Organization) basedon clinicopathologic features observed in a large group of patients. Blood 2002;99:800-5.

  2. Bradford PT, Devesa SS, Anderson WF, Toro JR. Cutaneous lymphoma incidencepatterns in the United States: a population-based study of 3884 cases. Blood.2009;113:5064-73.

  3. Elder DE, Massi D, Scolyer RA, Willemze R. WHO Classification of Skin Tumours. 4th ed. Lyon, France: IARC Press; 2018.

  4. Willemze R, Meijer CJ, Scheffer E, Kluin PM, Van Vloten WA,Toonstra J, Diffuse large cell lymphomas of follicular center cell origin presenting in the skin. A clinicopathologicand immunologic study of 16 patients. Am J Pathol1987;126:325‑33.

  5. Vermeer MH, Geelen FA, van Heselen CW, et al: Primarycutaneous large B-cell lymphomas of the legs. A distinct typeof cutaneous B-cell lymphoma with an intermediate prognosis. Dutch Cutaneous Lymphoma Working Group. Arch Dermatol1996;132:1304-8.

  6. Golling P, Cozzio A, Dummer R, French L, Kempf W. Primary cutaneous B-celllymphomas - clinicopathological, prognostic and therapeutic characterization of 54 cases according to the WHO-EORTC classification and the ISCL/EORTCTNM classification system for primary cutaneous lymphomas other than mycosisfungoides and Sezary syndrome. Leuk Lymphoma. 2008;49:1094-103.

  7. Jia et al. Primary cutaneous diffuse large B cell lymphomaothersuccessfully treated by the combinationof R-CHOP chemotherapy and surgeryA case report and review of literatureMedicine (2017) 96:8

  8. Massone C, Fink-Puches R, Wolf I, et al. Atypical clinicopathologicpresentation of primary cutaneous diffuse large B-cell lymphoma, legtype. J Am AcadDermatol 2015;72:1016–20.

  9. Yaripour S, Dehghan A, Janbaz P. Diffuse Large B-Cell Lymphoma Involving of Face - A Case Report and a Brief Review. Clin Surg. 2017; 2: 1505.

  10. Muniesa C, Pujol RM, Estrach MT, et al. Primary cutaneous diffuse large B-cell lymphoma, leg type and secondary cutaneous involvement by testicular B-cell lymphoma share identical clinicopathological and immunophenotypical features. J Am AcadDermatol 2012;66:650–4.

  11. Bhardwaj S, Ahluwalia C, Mandal A K. Vimentin Positive Primary Thyroid Diffuse Large B-Cell Lymphoma: cytological diagnosis of two cases. Annals of Pathology and Laboratory Medicine.2017;4(3): 78-81.

  12. Willemze, R., Hodak, E., Zinzani, P. L., Specht, L., &Ladetto, M. (2018). Primary cutaneous lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Annals of Oncology, 29(Supplement_4), iv30–iv40. doi:10.1093/annonc/mdy133 

 To cite this article:

Kumari M, Ahluwalia C. An ulcero-proliferative lesion over left cheek- a diagnostic dilemma.. Int. J. Med. Lab. Res. 2021; 6,1:45-49.

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