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Research Article






Madhu. Divakar*, Lins Mary Joy

Abstract: Objective: The present animal experimentation study is planned to screen the immunostimulant efficacy, free radical scavenging potential and the acute toxicity of the bracket fungus, Ganoderma applanatum . Methods: The study analyse the invitro immunostimulant activity by phagocytic index determination using Candida albicans, acute toxicity study by brine shrimp assay and the free radical scavenging activities of G. applanatum solvent extracts. Conclusion: The percentage immunostimulation was found to be 88% for the chloroform-methanol (1:1) Ganoderma applanatum extract (GAE). The free radical scavenging activity studies were performed by utilising invitro model of hydroxyl, superoxide and lipid peroxide radical generating system. Results indicated that GAE at 100 mcg/ml showed 88.1, 89.19, and 81.87 % scavenging activity of hydroxyl, superoxide and lipid peroxide radical respectively. The LC50 was determined using brine shrimp assay method and calculated as 875 mcg /ml. The present study shows that G. applanatum can be utilised as an effective natural supplement to impart immunostimulation. 


KEYWORDS: Ganoderma applanatum, Immunostimulant activity, free radical scavenging activity 


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 To cite this article:

CD Madhu, JM Lins. Immunostimulant and free radical scavenging studies of ganoderma applanatum . Int. J. Med. Lab. Res. 2023; 8,1:21-25.

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