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Research Articles





*Rajini Kurup, Candacy Clarke, Odessa Trim

ABSTRACT: BACKGROUND: In countries like Guyana, where there is a heavy Tuberculosis (TB) burden, delays in the diagnosis of TB can have a detrimental outcome. This concern has led to invention and evaluation of different approaches to TB laboratory diagnosis. In this study, we compared the performance of light-emitting diode (LED) fluorescent microscopy (FM) and GeneXpert for the diagnosis of tuberculosis. METHODS: A retrospective study was conducted between September 2014 and July 2016. Data was extracted from the National Public Health Reference Laboratory Log books. RESULTS: A total of 568 patients were included based on their test results containing data on GeneXpert and LED FM. This study found that GeneXpert and LED FM was able to detect MTB in 162 (29%) and 76 (13%) cases respectively. The detection rate among HIV infected patient was higher with 69% for GeneXpert and 28% for LED FM. The Rifampicin resistance was found 14.2% in PTB patients. CONCLUSION: It can be concluded from this research that the detection rate of GeneXpert is much higher than that of the LED FM when testing for Tuberculosis. Thus, the implementation of GeneXpert can dramatically improve the diagnosis of tuberculosis and ultimately patient outcome.



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