International Journal of Medical Laboratory Research (IJMLR)

CLINICOHEMATOLOGICAL PROFILES OF HEPATITIS A VIRUS (HAV): A RETROSPECTIVE STUDY

 

Ramakrishna Pai Jakribettu, Thomas George, Rashmi Mathai, Muhammad Adnan, Taresh Naik, Manjeshwar Shrinath Baliga

​

ABSTRACT: Aim: Acute viral hepatitis A (HAV) is a major problem in parts of the developing countries. HAV is transmitted enterically and its incidence is high in places where poor hygienic conditions prevail. Most studies in the past have been on liver the primary organ affected by HAV and reports on extrahepatic organs are lacking. The present study was carried out to ascertain the alterations on the haematological, hepatic and renal parameters. Material and Methods: This was a retrospective study and was conducted in a tertiary care hospital in India. Data was analysed in people who expressed known symptoms of HAV and established by Anti-HAV IgM antibody. A total of 22 paediatric and 109 adult people were included in the study and compared with healthy individuals who were tested negative for infectious and chronic diseases. Results: The results indicated that jaundice, vomiting and fever were the predominant clinical symptom seen in both children and adults. There was significant difference in the various haematological, hepatic and electrolyte endpoints (p < 0.05 to 0.0001), while there was no such difference in the renal function test parameters. Conclusion: The present study indicates that acute infection with HAV causes alterations in haematological, hepatic parameters and in the levels of electrolytes in the serum.

 

KEY WORDS: Hepatitis A Virus (HAV); clinical, haematological; hepatic; renal.

​

REFERENCES:

 

1. Lankarani KB, Mahmoodi M, Honarvar B, Nematollahi P, Zamiri N, Ghaffarpasand F. Determinants of poor outcome in patients with hepatitis A infection: a four-year retrospective study in Shiraz, Southern Iran. Arch Virol. 2014; 159(8):1901–7.

2. Jamali R. Epidemiologic Studies on Viral Hepatitis: A Short Re­view. Thrita. 2014; 3(1): e15376.

3. Jacobsen KH, Wiersma ST. Hepatitis A virus seroprevalence by age and world region, 1990 and 2005. Vaccine. 2010; 28(41):6653-7.

4. Wasley A, Fiore A, Bell BP. Hepatitis A. In the era of vaccination. Epidemiol Rev. 2006; 28: 101-11.

5. Nainan OV, Xia G, Vaughan G, Margolis HS. Diagnosis of hepatitis a virus infection: a molecular approach. Clin Microbiol Rev. 2006; 19:63-79.

6. Takahashi Y, Okuda K. Fulminate and sub fulminant hepatitisin Japan _ Etiological considerations. Indian J Gastroentrol. 1993; 13: 19-21.

7. Lednar WM, Lemon SM, Kirkpatrick JW, et al. Frequency of illness associated with epidemic hepatitis A virus infections in adults. Am J Epidemiol 1985; 122:226–33.

8. Koff RS. Clinical manifestations and diagnosis of hepatitis A virus infection. Vaccine. 1992;10 Suppl 1:S15-7.

9. Cuthbert JA. Hepatitis A: old and new. Clin Microbiol Rev. 2001;14(1):38-58..

10. Tong S, Li J, Wands JR, Wen Y. Hepatitis B virus genetic variants: biological properties and clinical implications. Emerging Microbes & Infections. 2013;2(3):e10-16.

11. Centers for Disease Control and Prevention. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 1999; 48(RR-12):1–37

12. Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL. Harrison’s Principles of Internal Medicine. 5th ed.; 2001. p. 1694-710

13. WHO. The Global Prevalence of Hepatitis A Virus Infection and Susceptibility: A Systematic Review (Refered on October 10th 2015). Available from: URL: whqlibdoc.who.int/hq/2010/WHO_IVB_10.01_eng.pdf

14. Anonymous. Monocytes. http://www.hepatitiscentral.com/hcv/labs/monocytes/

15. Krugman S, Giles JP. Viral hepatitis: new light on an old disease. JAMA 1970; 212:1019–29

16. Theise ND. Liver and Gall bladder. Chapter 18 In: Kumar V, Abbas A K, Aster J C editors. Robbins and Cotran Pathologic Basis of Disease.: 9th ed.South Asia Edition Vol II.Elsevier Inc.; 2014.p.821-882.