Research Articles

      Abstract    

        

CLINICOHEMATOLOGICAL PROFILES OF HEPATITIS A VIRUS (HAV): A RETROSPECTIVE STUDY

 

Ramakrishna Pai Jakribettu, Thomas George, Rashmi Mathai, Muhammad Adnan, Taresh Naik, Manjeshwar Shrinath Baliga

ABSTRACT: Aim: Acute viral hepatitis A (HAV) is a major problem in parts of the developing countries. HAV is transmitted enterically and its incidence is high in places where poor hygienic conditions prevail. Most studies in the past have been on liver the primary organ affected by HAV and reports on extrahepatic organs are lacking. The present study was carried out to ascertain the alterations on the haematological, hepatic and renal parameters. Material and Methods: This was a retrospective study and was conducted in a tertiary care hospital in India. Data was analysed in people who expressed known symptoms of HAV and established by Anti-HAV IgM antibody. A total of 22 paediatric and 109 adult people were included in the study and compared with healthy individuals who were tested negative for infectious and chronic diseases. Results: The results indicated that jaundice, vomiting and fever were the predominant clinical symptom seen in both children and adults. There was significant difference in the various haematological, hepatic and electrolyte endpoints (p < 0.05 to 0.0001), while there was no such difference in the renal function test parameters. Conclusion: The present study indicates that acute infection with HAV causes alterations in haematological, hepatic parameters and in the levels of electrolytes in the serum.

 

KEY WORDS: Hepatitis A Virus (HAV); clinical, haematological; hepatic; renal.

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