Research Articles

      Abstract    

        

LEVELS OF TROPNIN AND CREATINE KINASE MB IN MYOCARDIAL INFARCTION PATIENTS

 

Tariq Elfatih Elmisbah, Mohammed Aiderous

 

ABSTRACT:

Background.Myocardial infarction (MI) commonly known as a heart attack occurs when blood flow stops to part of the heart causing damage to the heart muscle. Troponin, or troponin  complex, is acomplex of three regulatory proteins( troponinC, troponon1, and troponin T),that is integral to cardiac muscles. An increased level of the cardiac protein isoform of troponin circulating in the blood has been showen to be a biomarker of heart disorders, the most important of which is myocardialinfarction. Creatine kinase –MB is an enzyme found in the heart and rises when heart muscle is damaged. Study design. This study was designed  asa case control study in aceer state, Saudi Arabia to determine the frequency of determine the levels of tropnine and creatine MB in myocardial infarction patients. Materials and methods. One hundred fifty Saudi myocardial infarction patients admitted to KhamisMushiat central hospital in KSAduring the period from March 2016-april 2017 were recruited to participate in this study as well as fifty apparently healthy volunteers were enrolled as a control group. A venous blood 2.7ml sample was collected in a plastic tube vacationer containing sodium citrate anticoagulant for immunological analysis Non-probability sampling method was used. A sandwich electrochemiluminescence immunoassay which employs 2 monoclonal antibodies was used. Results.  Results showed that the mean of troponin among study sample was increased in compared to control (P.value issignificant), and also the study showed that the mean of creatine kinase MB levels was increased in compared with control(P.value is significant). Conclusion. This study proved that the levels of troponine and creatine kinase were increased in myocardial infarction patients.

KEY WORDS: Myocardial infarction, troponin, creatine kinase MB

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