Research Articles

      Abstract    

        

ALTERATIONS IN HEMATOLOGICAL, LIVER AND RENAL PARAMETER LEVELS IN PEOPLE AFFLICTED WITH LUNG CANCER

 

SK Chandran , S Rao , K Prasad , S Hegde , SB Kunhanna , AK Kudva , MS Baliga

 

ABSTRACT: Background: Lung cancer is one of the most cancers in the world. It has a bad prognosis and is associated with high cancer related mortality. The present study was carried out to ascertain the alterations in the haematological, hepatic and renal parameters in lung cancer patients who were yet to receive any treatment by comparing with healthy individuals (control cohort). Methods: This was a prospective study and was conducted in a superspeciality cancer care hospital at Mangalore, Karnataka, India. The study participants included people who were confirmed to have been afflicted with lung cancer and before start of any treatment. Data was collected after obtaining the ethics committee permission and patient’s informed consent from December 2017 to February 2018. The standard blood data required for ascertaining the general health conditions were collected from patient file and analysed. Results: During the study time period, 13 females 32 males were diagnosed with lung cancer and agreed to be part of the study.  When compared to the healthy individuals, some of the haematological, liver and kidney parameters were altered in either the males or in females (p< 0.05 to 0.0002).  Conclusion: The present study indicates that there was a marked difference in the haematological, hepatic and renal parameters in people afflicted with lung cancer.

 

KEY WORDS: Lung cancer, clinical, haematological; hepatic; renal parameters.

REFERENCES:

  1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136(5):E359-86.

  2. Wong MCS, Lao XQ, Ho KF, Goggins WB, Tse SLA. Incidence and mortality of lung cancer: global trends and association with socioeconomic status. Sci Rep. 2017; 7(1):14300. doi: 10.1038/s41598-017-14513-7.

  3. Khuder SA. Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis. Lung Cancer. 2001; 31(2-3):139-48.

  4. Jee SH, Park JY, Kim HS, Lee TY, Samet JM. White blood cell count and risk for all-cause, cardiovascular, and cancer mortality in a cohort of Koreans. Am J Epidemiol 2005; 162:1062–9.

  5. Madjid M, Awan I, Willerson JT, Casscells SW. Leukocyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol. 2004;44(10):1945–56

  6. Kruse AL, Luebbers HT, Grätz KW. Evaluation of white blood cell count as a possible prognostic marker for oral cancer.Head Neck Oncol.2011;3:13.doi:10.1186/1758-3284-3-13

  7. Bhattacharjee A, Borah FR, Giri S, Bapan D, Uddin S.“Evaluation of Hematological Parameters as a Possible Marker for Head-and-Neck Cancer and Precancerous Conditions.” Journal of Evolution of Medical and Dental Sciences 2015; 4(95); 22-27.

  8. Laursen I, Briand P, Lykkesfeldt AE (1990). Serum albumin as a modulator on growth of the human breast cancer cell line, MCF-7. Anticancer Res, 10, 343-51.

  9. Sonnenschein C, Soto AM, Michaelson CL (1996). Human serum albumin shares the properties of estrocolyone-I, the inhibitor of the proliferation of estrogen-target cells. J Steroid Biochem Mol Biol, 59, 147-54

  10. Ying-Jian Song, Xin-Huai Gao, Yong-Qing Hong and Li-Xin Wang. Direct bilirubin levels are prognostic in non-small cell lung cancer. Oncotarget, 2018, Vol. 9, (No. 1), pp: 892-900.

  11. Horsfall LJ, Rait G, Walters K, Swallow DM, Pereira SP, Nazareth I, Petersen I. Serum bilirubin and risk of respiratory disease and death. JAMA. 2011; 305:691–7.

  12. 12 Winter MC, Potter VA, Woll PJ. Raised serum urea predicts for early death in small cell lung cancer. Clin Oncol (R Coll Radiol). 2008; 20(10):745-50

Basics and upadate on flow cytometry related research

IJMLR events

   Article are invited for

         Vol 5, Issue 3,

         Sep-Dec 2020

  • Facebook - Black Circle
  • Google+ - Black Circle

Copyright © 2016 International Journal of Medical Laboratory Research. All right reserved

             mail