International Journal of Medical Laboratory Research (IJMLR)

A REVIEW STUDY ON EFFICACY OF IMMUNOMODULATORY AGENTS USED FOR THE TREATMENT OF COVID-19

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AU Kurya, AU Toro, UR Bello, DC Sharma

 

ABSTRACT: The infection started at December, 2019 with the random elevation of respiratory tract disorders at Wuhan hospital in China. Sequencing of lower respiratory tract samples by independent laboratories in china identified a novel corona virus distinct from the other SARS strains of coronavirus previously known to infect humans, which was earlier named as corona virus disease 2019 (COVID-19) by the world health organization. The present review work highlighted the outbreaks of COVID-19 on the basis of research articles published in the reputed research articles and other authentic sources. Increased morbidity and mortality rate in COVID-19 is largely associated with acute respiratory distress syndrome (ARDS). Throughout the period of SARS, MERS infections, and SARS CoV-2, Elevated level of proinflammatory cytokines and chemokine was commonly observed in patients requiring ICU admission as compared to those in which the infection was less severe and did not require ICU admission due to excessive immune responses induced by the immune system. Potential of immunomodulatory agents such as IL-1 and IL-6 receptor antagonist, TNF-α blockers and corticosteroids in treatment of COVID-19 declared urgent need for clinical researches to precisely confirm the effectiveness and safety of the therapeutics.

 

KEY WORDS: COVID-19, Cytokines, Coronavirus and Immunotherapy.

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