top of page
Research Article





A Challapalli, F Fazal , MLJ Pais, M Adnan, RP Jakribettu, R Boloor, MS Baliga


ABSTRACT: Background: Globally, tuberculosis (TB) is one of the top 10 causes of death and India, is one among the leading contributors. This study was undertaken to assess the clinic-laboratory profile of the patients diagnosed with Pulmonary TB (PTB) and evaluate differences between dead and alive PTB patients. Material and methods: : This is a retrospective study, conducted in the patients diagnosed with PTB from January 2016 to December 2018. The clinical, hematological and biochemical parameters of the patients diagnosed with Pulmonary TB at the time of presentation to the tertiary care hospital was noted and compared among the age matched healthy individuals. We further looked for prognostic factors among the tuberculosis patients who died and survived.  Results: A total of 209 patients were diagnosed with PTB during the study period. The prevalence of TB was higher in males. Most of the TB patients belonged to the age group 31-60 years. Among the PTB patients, cough with expectoration was the most common symptoms followed by fever and breathlessness. Nearly 50% patients had symptoms for less than 2 weeks. The right upper zone was the most common zone involved radiologically. When compared to healthy individuals, TB patients had significantly low haemoglobin, while there was raise in total leukocyte count, platelet count ESR, Blood urea, and LFT. The mortality in TB patients was associated with low haemoglobin, lower differential macrophage count and lower globulin.  Conclusion: In our study population, PTB was common in males, and in age group of 31-60 years. Patients with Cough with expectoration with 2 weeks duration, anaemic, leucocytosis and raised ESR must be investigated extensively for Pulmonary TB. Patients (PTB) with were severe anaemia and lower differential macrophage count had higher mortality rate.


KEY WORDS: Tuberculosis, haematological, biochemical, TB Mortality


  1. Global tuberculosis report 2018. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO.

  2. The End TB Strategy Global strategy and targets for tuberculosis prevention, care and control after 2015. Geneva: World Health Organization; 2014.

  3. Lawn SD, Zumla AI (July 2011). "Tuberculosis". Lancet; 378, 9785: 57–72. 

  4.  Dolin, [edited by] Gerald L. Mandell, John E. Bennett, Raphael (2010).  Mandell, Douglas, and Bennett's principles and practice of infectious diseases (7th ed.). Philadelphia, PA: Churchill Livingstone/ Elsevier. pp. Chapter 250.

  5. Halezeroğlu S, Okur E (March 2014). "Thoracic surgery for haemoptysis in the context of tuberculosis: what is the best management approach?". Journal of Thoracic Disease. 6,3: 182–5. 

  6. Berry FB. Tuberculouspyopneumothorax with pyogenic infection. J ThoracSurg 1932; 2:139.

  7. Rosenzweig DY, Stead WW. The role of tuberculosis and other forms of bronchopulmonary necrosis in the pathogenesis of bronchiectasis. Am Rev Respir Dis 1966; 93:769.

  8. Jethani S, Kakkar R, Semwal J, Rawat J. Socio Demographic Profile of Tuberculosis patient: A hospital based study at Dehradun. Natl J Community Med 2014; 5, 1: 6-9.

  9. Rohit R T, Niranjan A, Paharam, Pawan P A. Socio-demographic profile and outcome of TB patients registered at DTC Rewa of Central India. Indian Journal of Tuberculosis.2018;65,2: 140-144,

  10. Bergdorf M, Nagelkerke N, Dye C, Nunn P. Gender and tuberculosis: a comparison of prevalence surveys with notification data to explore sex differences in case detection. Int J Tuberc Lung Dis. 2000; 4:123–132.

  11. Jha A. An Epidemiological Study of Pulmonary Tuberculosis in the Field Practice Areas. Dehradun: HNB Garhwal 2010.

  12.  Fraser RS, Muller NL, Colman N, Pare PD. Frazer and Pare’s Diagnosis of Diseases of the Chest. 4th ed. Philadelphia, Pa: Saunders; 1999:798-875

  13. Rohini K, Bhat M S, Srikumar P S, Kumar M A. Assessment of Hematological Parameters in Pulmonary Tuberculosis Patients. Ind J ClinBiochem 2016; 31,3:332–335.

  14. Singh K J, Ahluwalia G, Sharma SK, Saxena R, Chaudhary VP, Anant M. Significance of haematological manifestations in patients with tuberculosis. J Assoc Physicians India. 2001; 49:788, 790-4.

  15. Even Abay, Aregawi Yalew, Agumas Shibabaw, and Bamlaku Enawgaw, “Hematological Abnormalities of Pulmonary Tuberculosis Patients with and without HIV at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-Sectional Study,” Tuberculosis Research and Treatment 2018; 2018: 5740951.

  16. Pandit A, Pandey AK. Liver Dysfunction in Pulmonary Tuberculosis Patients on DOTS: A Study and Review. Journal of Gastroenterology and Hepatology Research 2016; 5,6: 2254-2260.

  17. Lingaraja M, Venugopal K, Shashibushan J, Naik S: A Study of Liver Function Tests Abnormalities In Tuberculosis Patients Under Rntcp-Dots, Vims Bellary. PJSR 2015; 8 ,1:28-33.

 To cite this article:

Challapalli A, Fazal F , Pais MLJ , Adnan M, Jakribettu RP, Boloor R, Baliga MS. Clinico-laboratory profile of patients affected with pulmonary tuberculosis: retrospective observations from a tertiary care hospital. Int. J. Med. Lab. Res. 2020; 5,2:20-26.

bottom of page