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Research Article





V O Ekundina, A A Oladele, H T Wilson, N Y Hassan, J O Sanya


ABSTRACT: Background and aim: Monitoring and diagnosis of benign or premalignant lesions as it progresses to a malignant condition is very necessary as its importance is the probability of its ability to predict or curb progression to the malignant condition and Immunohistochemistry could be a useful tool in achieving this as immunohistochemical markers are specific in nature. The purpose of this study is to demonstrate the expression of the immunohistochemical markers; BCL-2, E cadherin and PSA (prostate specific antigen) in BPH and PCa and their ability to be useful in the prediction of the progression to Prostatic malignant lesions.  Sample and method: A total of 60 tissue blocks were retrieved from the pathology archive, previously collected from males histologically confirmed to be present with previously untreated BPH and malignant cases (PCa), consisting 10 normal cases (control), 20 BPH cases and 30 PCa cases which consisted of both LGPIN and HGPIN. Immunohistochemical analysis was carried out on the samples. The immunohistochemical staining was evaluated and the results were considered.  Result: Cytoplasmic BCL-2 staining was expressed, Membrane staining of E-cadherin was expressed and cytoplasmic PSA was expressed within the cells of normal, BPH and PCa tissues. There was an upregulation of BCL-2 and down regulation of E-cadherin in the progression to the malignant condition and PSA showed a reduced expression in undifferentiated malignancy. Conclusion: The expression of BCL-2, E-cadherin and PSA in Normal, BPH and malignant prostatic tissue has confirmed the ability of immunohistochemistry (its markers) tosurveil the progression of prostate cancer.


KEY WORDS: Prostate cancer, Benign prostatic hyperplasia, BCL-2, E-cadherin, PSA


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 To cite this article:

Ekundina V O , Oladele A A, Wilson H T , Hassan N Y, Sanya J O. Diagnostic utility of bcl-2, e-cadherin and psa in the progression of malignant prostatic lesions. Int. J. Med. Lab. Res. 2021; 6,1:1-10.

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