International Journal of Medical Laboratory Research (IJMLR)

FREQUENCIES OF RHESUS BLOOD GROUP SUBTYPES, AND PROBABLE GENOTYPES IN SUDANESE POPULATION

 

Malik H I Mustafa, Tariq E Elmissbah, E A G Khalil

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ABSTRACT: Background. This is a community-based, prospective, and analytical study aimed to determine the frequencies of Rhesus blood group (Rh) alleles, haplotypes, and probable genotypes, and establishing baseline data. Materials and Methods. Following informed consent, a total of 1,000 venous blood samples from unrelated individuals were collected. Particle gel immunological diffusion and slide agglutination procedures were used to screen red blood cells for common Rhesus antigens. The frequencies of genes/alleles and haplotypes, as well as the most likely genotypes, were determined. Jaccard's coefficient of similarities was used to calculate similarities between different Sudanese populations. The same coefficient was used to figure out where these people came from. Results. The ē,  and the D genes were the commonest alleles detected with frequencies of 98.4%, 93.8% and 90.7% respectively. The C and the E genes were the least frequent with 58.4% and 21.0% frequencies respectively. The Commonest Rh genotype encountered was the  (frequency= 44.2%). The  and  genotypes were detected with lower frequencies of 21.7% and 10.9% respectively, while ,  and  genotypes were the least common [frequencies 0.3%), 0.2% and 0.1% respectively]. The most probably common haplotypes complex was / (frequency= 44.2%) and the least common was / (frequency= 0.1%). Conclusion- The antigen e was found to be the most frequent in major Sudanese populations, when the frequency of E antigen was the least once. the frequency of c antigen among this study populations exhibited high frequency (99).

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KEYWORD:  blood groups, Rh phenotype frequencies, Sudan

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