International Journal of Medical Laboratory Research (IJMLR)

AEROBIC VAGINITIS (AV):DISEASE BURDEN, BACTERIOLOGICAL PROFILE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN IN WESTERN MAHARASHTRA.

 

Deepa Devhare

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Abstract: Vaginitis is a very common and recurrent infection in reproductive age group especially worrisome in pregnant females. If it is misdiagnosed, left untreated or wrongly treated can lead to serious complications. With this background present study was conducted to determine the prevalence, bacteriological profile and antimicrobial susceptibility of the pathogens causing aerobic vaginitis. Study was conducted over a period of 1year in which 241 vaginal swabs were processed for aerobic culture and gram stain. The organisms were identified and antimicrobial susceptibility was performed by Vitek 2 compact system. Out of 241 samples processed 37(15.4%) showed bacterial growth. S. aureus (40.5%), GBS (13.5%), E. coli (13.5%) and K. pneumoniae (13.5%) were the common pathogens isolated. Gram positive organisms showed highest sensitivity to Vancomycin and Linezolid. All gram negative bacteria were sensitive to Imipenem and Meropenem. This study recommends the laboratory based diagnosis of each clinically suspected case of vaginitis for appropriate management of patient. Addition of antibacterial agent in traditional empirical antifungal therapy for vaginitis is need of hour.
 

KEYWORDS: Aerobic vaginitis, prevalence, bacterial pathogens, antibiotic susceptibility testing.

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REFERENCES:​

1. 1.      Cherian A, Sasikumari, O. Microbial Profile of High Vaginal Swab from Women of Reproductive Age Group in a Tertiary Care Hospital. Int.J.Curr.Microbiol.App.Sci., 2017;6(7): 2366-2370.(C)

2. 2.      Krishnasamy L, Saikumar C, Kumaramanickavel G. Aerobic Bacterial Pathogens CausingVaginitis in Patients Attending A Tertiary Care Hospital and their Antibiotic Susceptibility Pattern.J Pure Appl Microbiol., 2019;13(2):1169-1174.

3. 3.      Forbes B.A., Daniel F.S., Alice S.W. Baily and Scott’s diagnostic microbiology. 12th ed. USA: Mosby Elsevier Company., 2007; 860.

4. 4.      Schorge J., Schaffer J, Halvorson L, Hoffman B,  Bradshaw K, Cunningham F.G. Williams Gynecology, Second Edition, New York : McGraw- Hill Company; 2012. Chap 3: p. 547.

5. 5.      Kumar G., Singh K. Microbial Profile of High Vaginal Swab From Symptomatic Women of Reproductive Age Group: Data from Tertiary Care Hospital. International Journal of Science and Research (IJSR), 2015; 4(7):2672-2673.

6. 6.      Wójkowska-Mach J, Pomorska-Wesołowska, M,  Romanik, M,  Romaniszyn, D. Prevalence and Antimicrobial Susceptibility Profiles of Microorganisms Associated with Lower Reproductive Tract Infections in Women from Southern Poland—Retrospective Laboratory-Based Study. Int. J. Environ. Res. Public Health., 2021; 18: 335.

7. 7.      Donati L., Di Vico A., Nucci M., Quagliozzi L., Spagnuolo T., Labianca A., et al. Vaginal microbial flora and outcome of pregnancy. Arch. Gynecol. Obstet., 2010; 281: 589-600.

8. 8.      Tansarli GS., Kostaras EK., Athanasiou S., Falagas ME. Prevalence and treatment of aerobic vaginitis among non-pregnant women: Evaluation of the evidence for an underestimated clinical entity. Eur. J. Clin. Microbiol. Infect. Dis., 2013; 32: 977-84.

9. 9.      Pereira N., Edlind T.D., Schlievert P.M., Nyirjesy P.Vaginal toxic shock reaction triggering desquamative inflammatory vaginitis. J. Low Genit. Tract Dis., 2013; 17: 88-91.

10. 10.  Seliga-Siwecka J.P, Kornacka M.K. Neonatal outcome of preterm infants born to mothers with abnormal genital tract colonization and chorioamnionitis: A cohort study. Early Hum. Dev. 2013; 89: 271–275.

11. 11.  Drekonja D,  Filice G,  Greer N et al. Antimicrobial stewardship in outpatient settings: A systematic review. Infect. Control Hosp. Epidemiol. 2015; 36: 142–152.

12. 12.  Sopia AR, Joseph PID, Kalyani M, Ananthi B, Dhanaraj S, Henry AJ. Aerobacterial Vaginosis among Women Attending an Infertility Clinic at a Tertiary Care Hospital in Chennai, India and Susceptibility Pattern of Isolates. J Pure Appl Microbiol. 2021;15(1):194-200.

13. 13.  Khan I, Khan UA. A hospital based study of frequency of aerobic pathogens in vaginal infections. J. Rawal Med. Coll., 2004; 29(1):22-5.

14. 14.  Sangeetha K.T., Golia S., Vasudha C.L. A study of aerobic bacterial pathogens associated with vaginitis in reproductive age group women (15-45 years) and their sensitivity pattern. Int. J. Res. Med. Sci., 2015; 3:2268-73.

15. 15.   Shaikh S, Waghmare P, Sharma A, Ingole K,  Bawane R. A Retrospective Evaluation of Vaginitis in Women of Reproductive Age Group in a Tertiary Care Hospital in Solapur, India. Int. J. Curr. Microbiol. App. Sci., 2018; 7(02): 762-768.                                          doi: https://doi.org/10.20546/ijcmas.2018.702.096.

16. 16.  Sharan H. Current Bacteriological Profile of Aerobic Vaginitis in a Tertiary Care Setup. J Pure Appl Microbi.,2016; 10(3): 2361-2365.

17. 17.   Lakshmi K, Chitralekha S, Illamani V, Menezes GA. Prevalence of bacterial vaginal infections in asymptomatic diabetic women. Jour of Med Sc & Tech., 2012; 1(3):9-15.

18. 18.  Swamy N, Ramalingappa P, Bhatara U. Antimicrobial Sensitivity Pattern of Microorganisms Isolated from Vaginal Infections at a Tertiary Hospital in Bangalore, India. International Journal of Medical Students, 2015; 3(1):34-39.

19. 19.  Ravishankar N, Prakash M. Antibiogram of Bacterial Isolates from High Vaginal Swabs of Pregnant Women from Tertiary Care Hospital in Puducherry, India. Int.J.Curr.Microbiol.App.Sci.,2017; 6(1): 964-972.