Research Articles

      Abstract    

        

CLINICOHEMATOLOGICAL PROFILES OF HEPATITIS C VIRUS (HCV): A RETROSPECTIVE HOSPITAL BASED STUDY

 

Jakribettu RP, George T, Rai MP, Sajan S, Challapalli A, Mathew JM, Baliga MS

ABSTRACT:Aim: Acute viral hepatitis C (HAC) is an important organ specific virus affecting the liver. The pathological sequelae of the infection are well documented and a detailed literature study indicates that most studies have been on liver the primary organ affected by HCV. Studies and observations on the effect of HCV on the extrahepatic organs are lacking. The present study was carried out to ascertain clinical presentations and the alterations on the haematological and hepatic parameters. Material and Methods: This was a retrospective study and was conducted in a tertiary care hospital in India. Data was collected and analysed in people who were confirmed to be affected only by HCV by the standard diagnostic method using the Anti HCV Antibody for the period January 2014 to June 2016. A total of 48 people were included in the study and compared with healthy individuals who were tested negative for any infectious and chronic diseases (annual health check up individuals). Results: The results indicated that during the study period, 48 individuals were tested positive for HCV. Of these, 35 were symptomatic, while 13 were asymptomatic and were diagnosed incidentally during routine/mandatory investigation before surgery. In the 35 symptomatic patients jaundice (82.85%) and loss of appetite (57.14%) were the two predominant clinical symptoms. There was a significant difference in the various haematological, hepatic and electrolyte endpoints (p < 0.05 to 0.0001).  Conclusion: The study indicates that acute infection with HCV causes changes in the alterations in haematological, hepatic and electrolytes in the serum.

KEY WORDS: Hepatitis C Virus (HCV); clinical, haematological, electrolytes.

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